ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ

Excessive nuclear factor-κB (NF-κB) activation mediated by tumor necrosis factor α (TNFα) plays a critical role in inflammation. Here we demonstrate that angiopoietin-like 8 (ANGPTL8) functions as a negative feedback regulator in TNFα-triggered NF-κB activation intracellularly. Inflammatory stimuli...

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Udgivet i:Nat Commun
Main Authors: Zhang, Yu, Guo, Xian, Yan, Wanyao, Chen, Yan, Ke, Mengxiang, Cheng, Cheng, Zhu, Xiuqin, Xue, Weili, Zhou, Qiaoqiao, Zheng, Ling, Wang, Shun, Wu, Bin, Liu, Xinran, Ma, Liang, Huang, Lianqi, Huang, Kun
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5735157/
https://ncbi.nlm.nih.gov/pubmed/29255244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02355-w
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