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ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ
Excessive nuclear factor-κB (NF-κB) activation mediated by tumor necrosis factor α (TNFα) plays a critical role in inflammation. Here we demonstrate that angiopoietin-like 8 (ANGPTL8) functions as a negative feedback regulator in TNFα-triggered NF-κB activation intracellularly. Inflammatory stimuli...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5735157/ https://ncbi.nlm.nih.gov/pubmed/29255244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02355-w |
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