N-Acetylcysteine Attenuates the Development of Renal Fibrosis in Transgenic Mice with Dilated Cardiomyopathy

Mechanisms underlying the renal pathology in cardiorenal syndrome (CRS) type 2 remain elusive. We hypothesised that renal glutathione deficiency is central to the development of CRS type 2. Glutathione precursor, N-acetylcysteine (NAC;40 mg/kg/day; 8 weeks) or saline were administered to transgenic...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Giam, Beverly, Kuruppu, Sanjaya, Chu, Po-Yin, Smith, A. Ian, Marques, Francine Z., Fiedler, April, Horlock, Duncan, Kiriazis, Helen, Du, Xiao-Jun, Kaye, David M., Rajapakse, Niwanthi W.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5735149/
https://ncbi.nlm.nih.gov/pubmed/29255249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17927-5
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