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Trypsin-Ligand binding affinities calculated using an effective interaction entropy method under polarized force field

Molecular dynamics (MD) simulation in the explicit water is performed to study the interaction mechanism of trypsin-ligand binding under the AMBER force field and polarized protein-specific charge (PPC) force field combined the new developed highly efficient interaction entropy (IE) method for calcu...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Cong, Yalong, Li, Mengxin, Feng, Guoqiang, Li, Yuchen, Wang, Xianwei, Duan, Lili.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5735144/
https://ncbi.nlm.nih.gov/pubmed/29255159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17868-z
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