Partial CD25 Antagonism Enables Dominance of Antigen-Inducible CD25(high) FOXP3(+) Regulatory T Cells As a Basis for a Regulatory T Cell-Based Adoptive Immunotherapy

FOXP3(+) regulatory T cells (Tregs) represent a promising platform for effective adoptive immunotherapy of chronic inflammatory disease, including autoimmune diseases such as multiple sclerosis. Successful Treg immunotherapy however requires new technologies to enable long-term expansion of stable,...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Wilkinson, Daniel S., Ghosh, Debjani, Nickle, Rebecca A., Moorman, Cody D., Mannie, Mark D.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5735073/
https://ncbi.nlm.nih.gov/pubmed/29312311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01782
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