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Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment

Monoclonal antibodies (mAbs) can destroy tumors by recruiting effectors such as myeloid cells, or targeting immunomodulatory receptors to promote cytotoxic T cell responses. Here, we examined the therapeutic potential of combining a direct tumor-targeting mAb, anti-CD20, with an extended panel of im...

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Dades bibliogràfiques
Publicat a:Cancer Cell
Autors principals: Turaj, Anna H., Hussain, Khiyam, Cox, Kerry L., Rose-Zerilli, Matthew J.J., Testa, James, Dahal, Lekh N., Chan, H.T. Claude, James, Sonya, Field, Vikki L., Carter, Matthew J., Kim, Hyung J., West, Jonathan J., Thomas, Lawrence J., He, Li-Zhen, Keler, Tibor, Johnson, Peter W.M., Al-Shamkhani, Aymen, Thirdborough, Stephen M., Beers, Stephen A., Cragg, Mark S., Glennie, Martin J., Lim, Sean H.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5734932/
https://ncbi.nlm.nih.gov/pubmed/29198913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.11.001
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