Inhibiting DPP4 in a mouse model of HHT1 results in a shift towards regenerative macrophages and reduces fibrosis after myocardial infarction

AIMS: Hereditary Hemorrhagic Telangiectasia type-1 (HHT1) is a genetic vascular disorder caused by haploinsufficiency of the TGFβ co-receptor endoglin. Dysfunctional homing of HHT1 mononuclear cells (MNCs) towards the infarcted myocardium hampers cardiac recovery. HHT1-MNCs have elevated expression...

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Veröffentlicht in:PLoS One
Hauptverfasser: Dingenouts, Calinda K. E., Bakker, Wineke, Lodder, Kirsten, Wiesmeijer, Karien C., Moerkamp, Asja T., Maring, Janita A., Arthur, Helen M., Smits, Anke M., Goumans, Marie-José
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5734765/
https://ncbi.nlm.nih.gov/pubmed/29253907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0189805
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