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MICU2 Restricts Spatial Crosstalk Between InsP(3)R and MCU Channels by Regulating Threshold and Gain of MICU1-Mediated Inhibition and Activation of MCU

Ca(2+) entry into mitochondria is mediated by the Ca(2+) uniporter-channel complex containing MCU, the Ca(2+)-selective pore, and associated regulatory proteins. The roles of MICU proteins are controversial. MICU1 was proposed to be necessary for MCU activity whereas subsequent studies suggested it...

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Publicat a:Cell Rep
Autors principals: Payne, Riley, Hoff, Henry, Roskowski, Anne, Foskett, J. Kevin
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5734103/
https://ncbi.nlm.nih.gov/pubmed/29241542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.11.064
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