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MICU2 Restricts Spatial Crosstalk Between InsP(3)R and MCU Channels by Regulating Threshold and Gain of MICU1-Mediated Inhibition and Activation of MCU
Ca(2+) entry into mitochondria is mediated by the Ca(2+) uniporter-channel complex containing MCU, the Ca(2+)-selective pore, and associated regulatory proteins. The roles of MICU proteins are controversial. MICU1 was proposed to be necessary for MCU activity whereas subsequent studies suggested it...
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| Izdano u: | Cell Rep |
|---|---|
| Glavni autori: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5734103/ https://ncbi.nlm.nih.gov/pubmed/29241542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.11.064 |
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