Redox-Regulated Heterogeneous Thresholds for Ligand Recruitment among InsP(3)R Ca(2+)-Release Channels

To clarify the molecular mechanisms behind quantal Ca(2+) release, the graded Ca(2+) release from intracellular stores through inositol 1,4,5-trisphosphate receptor (InsP(3)R) channels responding to incremental ligand stimulation, single-channel patch-clamp electrophysiology was used to continuously...

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Détails bibliographiques
Auteurs principaux: Vais, Horia, Siebert, Adam P., Ma, Zhongming, Fernández-Mongil, Marisabel, Foskett, J. Kevin, Mak, Don-On Daniel
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2010
Sujets:
Cellular Biophysics and Electrophysiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905128/
https://ncbi.nlm.nih.gov/pubmed/20643058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.04.034
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