MicroRNA miR-128 represses LINE-1 (L1) retrotransposition by down-regulating the nuclear import factor TNPO1

Repetitive elements, including LINE-1 (L1), comprise approximately half of the human genome. These elements can potentially destabilize the genome by initiating their own replication and reintegration into new sites (retrotransposition). In somatic cells, transcription of L1 elements is repressed by...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Idica, Adam, Sevrioukov, Evgueni A., Zisoulis, Dimitrios G., Hamdorf, Matthias, Daugaard, Iben, Kadandale, Pavan, Pedersen, Irene M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2017
Pynciau:
RNA
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733588/
https://ncbi.nlm.nih.gov/pubmed/28974576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.807677
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