MicroRNA miR-128 represses LINE-1 (L1) retrotransposition by down-regulating the nuclear import factor TNPO1

Repetitive elements, including LINE-1 (L1), comprise approximately half of the human genome. These elements can potentially destabilize the genome by initiating their own replication and reintegration into new sites (retrotransposition). In somatic cells, transcription of L1 elements is repressed by...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Idica, Adam, Sevrioukov, Evgueni A., Zisoulis, Dimitrios G., Hamdorf, Matthias, Daugaard, Iben, Kadandale, Pavan, Pedersen, Irene M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
RNA
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733588/
https://ncbi.nlm.nih.gov/pubmed/28974576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.807677
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker