Discovery of JTZ-951: A HIF Prolyl Hydroxylase Inhibitor for the Treatment of Renal Anemia

[Image: see text] Inhibition of hypoxia inducible factor prolyl hydroxylase (PHD) represents a promising strategy for the discovery of a next generation treatment for renal anemia. We identified several 5,6-fused ring systems as novel scaffolds of the PHD inhibitor on the basis of pharmacophore anal...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Ogoshi, Yosuke, Matsui, Takuya, Mitani, Ikuo, Yokota, Masahiro, Terashita, Masakazu, Motoda, Dai, Ueyama, Kazuhito, Hotta, Takahiro, Ito, Takashi, Hase, Yasunori, Fukui, Kenji, Deai, Katsuya, Yoshiuchi, Hiromi, Ito, Soichiro, Abe, Hiroyuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2017
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733278/
https://ncbi.nlm.nih.gov/pubmed/29259755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00404
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