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Functional selectivity of GPCR-directed drug action through location bias
G protein-coupled receptors (GPCRs) are increasingly recognized to operate from intracellular membranes as well as the plasma membrane. The β(2)-adrenergic GPCR can activate Gs-linkedcyclic AMP (cAMP) signaling from endosomes. We show here that the homologous human β(1)-adrenergic receptor initiates...
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| Udgivet i: | Nat Chem Biol |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5733145/ https://ncbi.nlm.nih.gov/pubmed/28553949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2389 |
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