Cytomegalovirus-Specific T Cells Restricted by HLA-Cw*0702 Increase Markedly with Age and Dominate the CD8(+) T-Cell Repertoire in Older People

Cytomegalovirus (CMV) infection elicits a strong T-cell immune response, which increases further during aging in a process termed “memory inflation.” CMV downregulates the expression of HLA-A and HLA-B on the surface of infected cells to limit presentation of viral peptides to T-cells although HLA-C...

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Sparad:
Bibliografiska uppgifter
I publikationen:Front Immunol
Huvudupphovsmän: Hosie, Louise, Pachnio, Annette, Zuo, Jianmin, Pearce, Hayden, Riddell, Stanley, Moss, Paul
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2017
Ämnen:
Immunology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732243/
https://ncbi.nlm.nih.gov/pubmed/29312307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01776
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