DOPA decarboxylase modulates tau toxicity

BACKGROUND: The microtubule-associated protein tau accumulates into toxic aggregates in multiple neurodegenerative diseases. We found previously that loss of D2-family dopamine receptors ameliorated tauopathy in multiple models including a Caenorhabditis elegans model of tauopathy. METHODS: To bette...

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Bibliographic Details
Published in:Biol Psychiatry
Main Authors: Kow, Rebecca L., Sikkema, Carl, Wheeler, Jeanna M., Wilkinson, Charles W., Kraemer, Brian C.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732084/
https://ncbi.nlm.nih.gov/pubmed/28751068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2017.06.007
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