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Incorporation of β-amino acids enhances the antifungal activity and selectivity of the helical antimicrobial peptide aurein 1.2
Antimicrobial peptides (AMPs) are attractive antifungal drug candidates because they kill microbes via membrane disruption and are thus less likely to provoke development of resistance. Low selectivity for fungal vs. human cells and instability in physiological environments have limited the developm...
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| Publicado no: | ACS Chem Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5732081/ https://ncbi.nlm.nih.gov/pubmed/29091404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00843 |
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