Profiling of ribonucleotides and deoxyribonucleotides pools in response to DNA damage and repair induced by methyl methanesulfonate in cancer and normal cells

The absolute and relative pool sizes of deoxyribonucleotides (dRNs) are essential in DNA replication fidelity, DNA damage and repair. We found in this study that although DNA damage induced by methyl methanesulfonate (MMS) seemed similar in cancer (HepG2) and normal (LO2) cells, more extensive alter...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Guo, Jian-Ru, Li, Zheng, Wang, Cai-Yun, Kei Lam, Christopher Wai, Chen, Qian-Qian, Zhang, Wei-Jia, Wai Wong, Vincent Kam, Yao, Mei-Cun, Zhang, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5731908/
https://ncbi.nlm.nih.gov/pubmed/29254198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21521
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