Interstitial IgG antibody pharmacokinetics assessed by combined in vivo‐ and physiologically‐based pharmacokinetic modelling approaches

KEY POINTS: For therapeutic antibodies, total tissue concentrations are frequently reported as a lump sum measure of the antibody in residual plasma, interstitial fluid and cells. In terms of correlating antibody exposure to a therapeutic effect, however, interstitial pharmacokinetics might be more...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Physiol
Prif Awduron: Eigenmann, Miro J., Karlsen, Tine V., Krippendorff, Ben‐Fillippo, Tenstad, Olav, Fronton, Ludivine, Otteneder, Michael B., Wiig, Helge
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2017
Pynciau:
Computational Physiology and Modelling
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730850/
https://ncbi.nlm.nih.gov/pubmed/28960303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP274819
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