Interstitial IgG antibody pharmacokinetics assessed by combined in vivo‐ and physiologically‐based pharmacokinetic modelling approaches

KEY POINTS: For therapeutic antibodies, total tissue concentrations are frequently reported as a lump sum measure of the antibody in residual plasma, interstitial fluid and cells. In terms of correlating antibody exposure to a therapeutic effect, however, interstitial pharmacokinetics might be more...

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Bibliographic Details
Published in:J Physiol
Main Authors: Eigenmann, Miro J., Karlsen, Tine V., Krippendorff, Ben‐Fillippo, Tenstad, Olav, Fronton, Ludivine, Otteneder, Michael B., Wiig, Helge
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
Subjects:
Computational Physiology and Modelling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730850/
https://ncbi.nlm.nih.gov/pubmed/28960303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP274819
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