A High-Resolution Genome-Wide CRISPR/Cas9 Viability Screen Reveals Structural Features and Contextual Diversity of the Human Cell-Essential Proteome

To interrogate genes essential for cell growth, proliferation and survival in human cells, we carried out a genome-wide clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 screen in a B-cell lymphoma line using a custom extended-knockout (EKO) library of 278,754 single-guide RNAs...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Bertomeu, Thierry, Coulombe-Huntington, Jasmin, Chatr-aryamontri, Andrew, Bourdages, Karine G., Coyaud, Etienne, Raught, Brian, Xia, Yu, Tyers, Mike
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730719/
https://ncbi.nlm.nih.gov/pubmed/29038160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00302-17
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