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CRISPR-Cas9-Based Knockout of the Prion Protein and Its Effect on the Proteome

The molecular function of the cellular prion protein (PrP(C)) and the mechanism by which it may contribute to neurotoxicity in prion diseases and Alzheimer's disease are only partially understood. Mouse neuroblastoma Neuro2a cells and, more recently, C2C12 myocytes and myotubes have emerged as...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Mehrabian, Mohadeseh, Brethour, Dylan, MacIsaac, Sarah, Kim, Jin Kyu, Gunawardana, C . Geeth, Wang, Hansen, Schmitt-Ulms, Gerold
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260877/
https://ncbi.nlm.nih.gov/pubmed/25490046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114594
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