Synthesis and characterization of the first inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD)

N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) is a membrane-associated zinc enzyme that catalyzes the hydrolysis of N-acylphosphatidylethanolamines (NAPEs) into fatty acid ethanolamides (FAEs). Here, we describe the identification of the first small-molecule NAPE-PLD inhibitor, the quina...

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Publicado en:Chem Commun (Camb)
Autores principales: Castellani, Beatrice, Diamanti, Eleonora, Pizzirani, Daniela, Tardia, Piero, Maccesi, Martina, Realini, Natalia, Magotti, Paola, Garau, Gianpiero, Bakkum, Thomas, Rivara, Silvia, Mor, Marco, Piomelli, Daniele
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730275/
https://ncbi.nlm.nih.gov/pubmed/29143042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7cc07582k
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