m(6)A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway

N6 -methyladenosine (m(6)A) is the most common and abundant messenger RNA modification, modulated by ‘writers’, ‘erasers’ and ‘readers’ of this mark (1,2). In vitro data have shown that m(6)A influences all fundamental aspects of mRNA metabolism, mainly mRNA stability, to determine stem cell fates (...

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Gepubliceerd in:Nature
Hoofdauteurs: Li, Hua-Bing, Tong, Jiyu, Zhu, Shu, Batista, Pedro J., Duffy, Erin E., Zhao, Jun, Bailis, Will, Cao, Guangchao, Kroehling, Lina, Chen, Yuanyuan, Wang, Geng, Broughton, James P., Chen, Y. Grace, Kluger, Yuval, Simon, Matthew D., Chang, Howard Y., Yin, Zhinan, Flavell, Richard A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5729908/
https://ncbi.nlm.nih.gov/pubmed/28792938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature23450
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