m(6)A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway

N6 -methyladenosine (m(6)A) is the most common and abundant messenger RNA modification, modulated by ‘writers’, ‘erasers’ and ‘readers’ of this mark (1,2). In vitro data have shown that m(6)A influences all fundamental aspects of mRNA metabolism, mainly mRNA stability, to determine stem cell fates (...

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Udgivet i:Nature
Main Authors: Li, Hua-Bing, Tong, Jiyu, Zhu, Shu, Batista, Pedro J., Duffy, Erin E., Zhao, Jun, Bailis, Will, Cao, Guangchao, Kroehling, Lina, Chen, Yuanyuan, Wang, Geng, Broughton, James P., Chen, Y. Grace, Kluger, Yuval, Simon, Matthew D., Chang, Howard Y., Yin, Zhinan, Flavell, Richard A.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5729908/
https://ncbi.nlm.nih.gov/pubmed/28792938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature23450
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