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Allogeneic bone marrow transplant in the absence of cytoreductive conditioning rescues mice with β-thalassemia major

β-thalassemia is a group of inherited blood disorders that result in defects in β-globin chain production. Cooley anemia (CA), or β-thalassemia major, is the most severe form of the disease and occurs when an individual has mutations in both copies of the adult β-globin gene. Patients with CA fail t...

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Détails bibliographiques
Publié dans:Blood Adv
Auteurs principaux: Huo, Yongliang, Lockhart, Jonathan R., Liu, Shanrun, Fontenard, Suean, Berlett, Mike, Ryan, Thomas M.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5729620/
https://ncbi.nlm.nih.gov/pubmed/29296892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017009449
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