Possible role of intragenic DNA hypermethylation in gene silencing of the tumor suppressor gene NR4A3 in acute myeloid leukemia

Expression of the tumor suppressor gene NR4A3 is silenced in the blasts of acute myeloid leukemia (AML), irrespective of the karyotype. Although the transcriptional reactivation of NR4A3 is considered to have a broad-spectrum anti-leukemic effect, the therapeutic modalities targeting this gene have...

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Published in:Leuk Res
Main Authors: Shimizu, Ryo, Muto, Tomoya, Aoyama, Kazumasa, Choi, Kwangmin, Takeuchi, Masahiro, Koide, Shuhei, Hasegawa, Nagisa, Isshiki, Yusuke, Togasaki, Emi, Kawajiri-Manako, Chika, Nagao, Yuhei, Tsukamoto, Shokichi, Sakai, Shio, Takeda, Yusuke, Mimura, Naoya, Ohwada, Chikako, Sakaida, Emiko, Iseki, Tohru, Starczynowski, Daniel T., Iwama, Atsushi, Yokote, Koutaro, Nakaseko, Chiaki
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5729587/
https://ncbi.nlm.nih.gov/pubmed/27697661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2016.09.018
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