Gimatecan exerts potent antitumor activity against gastric cancer in vitro and in vivo via AKT and MAPK signaling pathways

BACKGROUND: We investigated antitumor activity and underlying mechanisms of DNA topoisomerase I (TopI) inhibitor gimatecan and irinotecan in gastric cancer (GC) in vitro cell lines and in vivo patient-derived xenograft (PDX) models. METHODS: GC cell lines SNU-1, HGC27, MGC803 and NCI-N87 were used t...

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Veröffentlicht in:J Transl Med
Hauptverfasser: Chen, Zuhua, Liu, Zhentao, Huang, Wenwen, Li, Zhongwu, Zou, Jianling, Wang, Jingyuan, Lin, Xiaoting, Li, Beifang, Chen, Dongshao, Hu, Yanting, Ji, Jiafu, Gao, Jing, Shen, Lin
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5729429/
https://ncbi.nlm.nih.gov/pubmed/29237470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-017-1360-z
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