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The clinical efficacy of Afatinib 30 mg daily as starting dose may not be inferior to Afatinib 40 mg daily in patients with stage IV lung Adenocarcinoma harboring exon 19 or exon 21 mutations

BACKGROUND: Afatinib is a second-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). Compared to cytotoxic chemotherapy, afatinib has been shown to have better efficacy in the treatment of non-small cell lung cancer harboring EGFR mutations. However, 40 mg daily as th...

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Bibliografske podrobnosti
izdano v:BMC Pharmacol Toxicol
Main Authors: Yang, Chih-Jen, Tsai, Ming-Ju, Hung, Jen-Yu, Lee, Mei-Hsuan, Tsai, Ying-Ming, Tsai, Yu-Chen, Hsu, Jui-Feng, Liu, Ta-Chih, Huang, Ming-Shyan, Chong, Inn-Wen
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5729426/
https://ncbi.nlm.nih.gov/pubmed/29237484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40360-017-0190-1
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