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The clinical efficacy of Afatinib 30 mg daily as starting dose may not be inferior to Afatinib 40 mg daily in patients with stage IV lung Adenocarcinoma harboring exon 19 or exon 21 mutations

BACKGROUND: Afatinib is a second-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). Compared to cytotoxic chemotherapy, afatinib has been shown to have better efficacy in the treatment of non-small cell lung cancer harboring EGFR mutations. However, 40 mg daily as th...

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Pubblicato in:BMC Pharmacol Toxicol
Autori principali: Yang, Chih-Jen, Tsai, Ming-Ju, Hung, Jen-Yu, Lee, Mei-Hsuan, Tsai, Ying-Ming, Tsai, Yu-Chen, Hsu, Jui-Feng, Liu, Ta-Chih, Huang, Ming-Shyan, Chong, Inn-Wen
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5729426/
https://ncbi.nlm.nih.gov/pubmed/29237484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40360-017-0190-1
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