Effect of Concurrent Src Kinase Inhibition with Short Duration Hypothermia on Ca(2+)/Calmodulin kinase IV (CaM Kinase IV) Activity and Neuropathology after Hypoxia-Ischemia in the Newborn Swine Brain

BACKGROUND: Hypoxia-Ischemia (HI) results in increased activation of Ca2+/Calmodulin kinase IV (CaM Kinase IV) mediated by Src kinase. Therapeutic Hypothermia (HT) ameliorates neuronal injury in the newborn. HYPOTHESIS: Inhibition of Src kinase concurrently with hypothermia further attenuates the hy...

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Bibliografiska uppgifter
I publikationen:Neonatology
Huvudupphovsmän: Kratimenos, Panagiotis, Koutroulis, Ioannis, Jain, Amit, Malaeb, Shadi, Delivoria-Papadopoulos, Maria
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5729087/
https://ncbi.nlm.nih.gov/pubmed/29024930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000480067
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