Opposing post-transcriptional control of InR by FMRP and LIN-28 adjusts stem cell based tissue growth

Although the intrinsic mechanisms that control whether stem cells divide symmetrically or asymmetrically underlie tissue growth and homeostasis, they remain poorly defined. We report that the RNA-binding protein, Fragile X Mental Retardation Protein (FMRP), limits the symmetric division, and resulti...

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Udgivet i:Cell Rep
Main Authors: Luhur, Arthur, Buddika, Kasun, Ariyapala, Ishara Surangi, Chen, Shengyao, Sokol, Nicholas
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728658/
https://ncbi.nlm.nih.gov/pubmed/29212015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.11.039
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