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Opposing post-transcriptional control of InR by FMRP and LIN-28 adjusts stem cell based tissue growth

Although the intrinsic mechanisms that control whether stem cells divide symmetrically or asymmetrically underlie tissue growth and homeostasis, they remain poorly defined. We report that the RNA-binding protein, Fragile X Mental Retardation Protein (FMRP), limits the symmetric division, and resulti...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Luhur, Arthur, Buddika, Kasun, Ariyapala, Ishara Surangi, Chen, Shengyao, Sokol, Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728658/
https://ncbi.nlm.nih.gov/pubmed/29212015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.11.039
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