Near-tetraploidy is associated with Richter transformation in chronic lymphocytic leukemia patients receiving ibrutinib

Ibrutinib is a highly effective targeted therapy for chronic lymphocytic leukemia (CLL). However, ibrutinib must be discontinued in a subset of patients due to progressive CLL or transformation to aggressive lymphoma (Richter transformation). Transformation occurs early in the course of therapy and...

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Dades bibliogràfiques
Publicat a:Blood Adv
Autors principals: Miller, Cecelia R., Ruppert, Amy S., Heerema, Nyla A., Maddocks, Kami J., Labanowska, Jadwiga, Breidenbach, Heather, Lozanski, Gerard, Zhao, Weiqiang, Gordon, Amber L., Jones, Jeffrey A., Flynn, Joseph M., Jaglowski, Samantha M., Andritsos, Leslie A., Blum, Kristie A., T. Awan, Farrukh, Rogers, Kerry A., Grever, Michael R., Johnson, Amy J., Abruzzo, Lynne V., Hertlein, Erin K., Blachly, James S., Woyach, Jennifer A., Byrd, John C.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2017
Matèries:
Clinical Trials and Observations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728464/
https://ncbi.nlm.nih.gov/pubmed/29296799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017007302
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