Near-tetraploidy is associated with Richter transformation in chronic lymphocytic leukemia patients receiving ibrutinib

Ibrutinib is a highly effective targeted therapy for chronic lymphocytic leukemia (CLL). However, ibrutinib must be discontinued in a subset of patients due to progressive CLL or transformation to aggressive lymphoma (Richter transformation). Transformation occurs early in the course of therapy and...

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Bibliografiska uppgifter
I publikationen:Blood Adv
Huvudupphovsmän: Miller, Cecelia R., Ruppert, Amy S., Heerema, Nyla A., Maddocks, Kami J., Labanowska, Jadwiga, Breidenbach, Heather, Lozanski, Gerard, Zhao, Weiqiang, Gordon, Amber L., Jones, Jeffrey A., Flynn, Joseph M., Jaglowski, Samantha M., Andritsos, Leslie A., Blum, Kristie A., T. Awan, Farrukh, Rogers, Kerry A., Grever, Michael R., Johnson, Amy J., Abruzzo, Lynne V., Hertlein, Erin K., Blachly, James S., Woyach, Jennifer A., Byrd, John C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2017
Ämnen:
Clinical Trials and Observations
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728464/
https://ncbi.nlm.nih.gov/pubmed/29296799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017007302
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