Near-tetraploidy is associated with Richter transformation in chronic lymphocytic leukemia patients receiving ibrutinib

Ibrutinib is a highly effective targeted therapy for chronic lymphocytic leukemia (CLL). However, ibrutinib must be discontinued in a subset of patients due to progressive CLL or transformation to aggressive lymphoma (Richter transformation). Transformation occurs early in the course of therapy and...

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Veröffentlicht in:Blood Adv
Hauptverfasser: Miller, Cecelia R., Ruppert, Amy S., Heerema, Nyla A., Maddocks, Kami J., Labanowska, Jadwiga, Breidenbach, Heather, Lozanski, Gerard, Zhao, Weiqiang, Gordon, Amber L., Jones, Jeffrey A., Flynn, Joseph M., Jaglowski, Samantha M., Andritsos, Leslie A., Blum, Kristie A., T. Awan, Farrukh, Rogers, Kerry A., Grever, Michael R., Johnson, Amy J., Abruzzo, Lynne V., Hertlein, Erin K., Blachly, James S., Woyach, Jennifer A., Byrd, John C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2017
Schlagworte:
Clinical Trials and Observations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728464/
https://ncbi.nlm.nih.gov/pubmed/29296799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017007302
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