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An intracytoplasmic β3 Leu718 deletion in a patient with a novel platelet phenotype
A novel heterozygous ITGB3 Leu718del shows loss of synchronization between the intracytoplasmic tail of β3 with that of αIIb. Decreased activation of αIIbβ3 accompanies enlarged platelets that contain giant granules and give a poor aggregation response.
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| Publicado no: | Blood Adv |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5728455/ https://ncbi.nlm.nih.gov/pubmed/29296966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2016002808 |
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