Aberrant activation of a gastrointestinal transcriptional circuit in prostate cancer mediates castration resistance

Prostate cancer exhibits a lineage-specific dependence on androgen signaling. Castration resistance involves reactivation of androgen signaling or activation of alternative lineage programs to bypass androgen requirement. We describe an aberrant gastrointestinal lineage transcriptome expressed in ~5...

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Publicado no:Cancer Cell
Main Authors: Shukla, Shipra, Cyrta, Joanna, Murphy, Devan A., Walczak, Edward G., Ran, Leili, Agrawal, Praveen, Xie, Yuanyuan, Chen, Yuedan, Wang, Shangqian, Zhan, Yu, Li, Dan, Wong, Wai Pung E., Sboner, Andrea, Beltran, Himisha, Mosquera, Juan Miguel, Sher, Jessica, Cao, Zhen, Wongvipat, John, Koche, Richard P., Gopalan, Anuradha, Zheng, Deyou, Rubin, Mark A., Scher, Howard I., Chi, Ping, Chen, Yu
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728174/
https://ncbi.nlm.nih.gov/pubmed/29153843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.10.008
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