Pak2 regulates myeloid-derived suppressor cell development in mice

Myeloid-derived suppressor cells (MDSCs) are CD11b(+)Gr1(+) cells that induce T-cell hyporesponsiveness, thus impairing antitumor immunity. We have previously reported that disruption of Pak2, a member of the p21-activated kinases (Paks), in hematopoietic stem/progenitor cells (HSPCs) induces myeloi...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Zeng, Yi, Hahn, Seongmin, Stokes, Jessica, Hoffman, Emely A., Schmelz, Monika, Proytcheva, Maria, Chernoff, Jonathan, Katsanis, Emmanuel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Phagocytes, Granulocytes, and Myelopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728145/
https://ncbi.nlm.nih.gov/pubmed/29296839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017007435
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