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Aggregation of an RNA-binding protein, not loss of heterochromatin, causes sterility of aging yeast cells
In yeast, heterochromatin silencing is reported to decline in aging mother cells causing sterility in old cells. This process is thought to reflect a decrease in the activity of the NAD(+)-dependent deacetylase Sir2. Here, we tested whether Sir2 becomes nonfunctional gradually or precipitously durin...
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| Publicado no: | Science |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5728107/ https://ncbi.nlm.nih.gov/pubmed/28302853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaj2103 |
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