TG02 inhibits proteasome inhibitor–induced HSF1 serine 326 phosphorylation and heat shock response in multiple myeloma

Proteasome inhibition activates multiple kinases in myeloma cells resulting in the phosphorylation of p53, HSP27, c-JUN, and HSF1. TG02 inhibits proteasome inhibitor (PI)–induced HSF1 pS326, representing a novel mechanism for a TG02 and PI combination.

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Vydáno v:Blood Adv
Hlavní autoři: Shah, Shardule P., Nooka, Ajay K., Lonial, Sagar, Boise, Lawrence H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2017
Témata:
Stimulus Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728095/
https://ncbi.nlm.nih.gov/pubmed/29296831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017006122
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