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Gene editing rescue of a novel MPL mutant associated with congenital amegakaryocytic thrombocytopenia
Thrombopoietin (Tpo) and its receptor (Mpl) are the principal regulators of early and late thrombopoiesis and hematopoietic stem cell maintenance. Mutations in MPL can drastically impair its function and be a contributing factor in multiple hematologic malignancies, including congenital amegakaryocy...
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| Yayımlandı: | Blood Adv |
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| Asıl Yazarlar: | , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society of Hematology
2017
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5728092/ https://ncbi.nlm.nih.gov/pubmed/29296828 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2016002915 |
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