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Gene editing rescue of a novel MPL mutant associated with congenital amegakaryocytic thrombocytopenia
Thrombopoietin (Tpo) and its receptor (Mpl) are the principal regulators of early and late thrombopoiesis and hematopoietic stem cell maintenance. Mutations in MPL can drastically impair its function and be a contributing factor in multiple hematologic malignancies, including congenital amegakaryocy...
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| Publicat a: | Blood Adv |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society of Hematology
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5728092/ https://ncbi.nlm.nih.gov/pubmed/29296828 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2016002915 |
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