Comprehensive Genomic Profiling of 282 Pediatric Low‐ and High‐Grade Gliomas Reveals Genomic Drivers, Tumor Mutational Burden, and Hypermutation Signatures

BACKGROUND. Pediatric brain tumors are the leading cause of death for children with cancer in the U.S. Incorporating next‐generation sequencing data for both pediatric low‐grade (pLGGs) and high‐grade gliomas (pHGGs) can inform diagnostic, prognostic, and therapeutic decision‐making. MATERIALS AND M...

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Veröffentlicht in:Oncologist
Hauptverfasser: Johnson, Adrienne, Severson, Eric, Gay, Laurie, Vergilio, Jo‐Anne, Elvin, Julia, Suh, James, Daniel, Sugganth, Covert, Mandy, Frampton, Garrett M., Hsu, Sigmund, Lesser, Glenn J., Stogner‐Underwood, Kimberly, Mott, Ryan T., Rush, Sarah Z., Stanke, Jennifer J., Dahiya, Sonika, Sun, James, Reddy, Prasanth, Chalmers, Zachary R., Erlich, Rachel, Chudnovsky, Yakov, Fabrizio, David, Schrock, Alexa B., Ali, Siraj, Miller, Vincent, Stephens, Philip J., Ross, Jeffrey, Crawford, John R., Ramkissoon, Shakti H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: AlphaMed Press 2017
Schlagworte:
Neuro‐Oncology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728033/
https://ncbi.nlm.nih.gov/pubmed/28912153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2017-0242
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