Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy

Tauopathies are a group of disorders in which the cytosolic protein tau aggregates and accumulates in cells within the brain, resulting in neurodegeneration. A promising treatment being explored for tauopathies is passive immunization with anti-tau antibodies. We previously found that administration...

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Publicado no:Sci Transl Med
Main Authors: Yanamandra, Kiran, Patel, Tirth K., Jiang, Hong, Schindler, Suzanne, Ulrich, Jason D., Boxer, Adam L., Miller, Bruce L., Kerwin, Diana R., Gallardo, Gilbert, Stewart, Floy, Finn, Mary Beth, Cairns, Nigel J., Verghese, Philip B., Fogelman, Ilana, West, Tim, Braunstein, Joel, Robinson, Grace, Keyser, Jennifer, Roh, Joseph, Knapik, Stephanie S., Hu, Yan, Holtzman, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727571/
https://ncbi.nlm.nih.gov/pubmed/28424326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aal2029
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