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The unfolded protein response impacts melanoma progression by enhancing FGF expression and can be antagonized by a chemical chaperone
The mechanisms hallmarking melanoma progression are insufficiently understood. Here we studied the impact of the unfolded protein response (UPR) - a signalling cascade playing ambiguous roles in carcinogenesis - in melanoma malignancy. We identified isogenic patient-derived melanoma cell lines harbo...
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| Pubblicato in: | Sci Rep |
|---|---|
| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5727496/ https://ncbi.nlm.nih.gov/pubmed/29235576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17888-9 |
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