Low-Density Lipoprotein Receptor Deficiency Attenuates Neuroinflammation through the Induction of Apolipoprotein E

OBJECTIVE: We aimed to determine the role of the low-density lipoprotein receptor (LDLr) in neuroinflammation by inducing experimental autoimmune encephalomyelitis (EAE) in ldlr knock out mice. METHODS: MOG(35–55) induced EAE in male and female ldlr(−/−) mice was assessed clinically and histopatholo...

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Udgivet i:Front Immunol
Main Authors: Mailleux, Jo, Timmermans, Silke, Nelissen, Katherine, Vanmol, Jasmine, Vanmierlo, Tim, van Horssen, Jack, Bogie, Jeroen F. J., Hendriks, Jerome J. A.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727422/
https://ncbi.nlm.nih.gov/pubmed/29276512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01701
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