Disabling a Type I-E CRISPR-Cas Nuclease with a Bacteriophage-Encoded Anti-CRISPR Protein

CRISPR (clustered regularly interspaced short palindromic repeat)-Cas adaptive immune systems are prevalent defense mechanisms in bacteria and archaea. They provide sequence-specific detection and neutralization of foreign nucleic acids such as bacteriophages and plasmids. One mechanism by which pha...

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Veröffentlicht in:mBio
Hauptverfasser: Pawluk, April, Shah, Megha, Mejdani, Marios, Calmettes, Charles, Moraes, Trevor F., Davidson, Alan R., Maxwell, Karen L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727412/
https://ncbi.nlm.nih.gov/pubmed/29233895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01751-17
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