Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques

Mouse and nonhuman primate models now serve as useful platforms to study Zika virus (ZIKV) pathogenesis, candidate therapies, and vaccines, but they rely on needle inoculation of virus: the effects of mosquito-borne infection on disease outcome have not been explored in these models. Here we show th...

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Publicado en:Nat Commun
Main Authors: Dudley, Dawn M., Newman, Christina M., Lalli, Joseph, Stewart, Laurel M., Koenig, Michelle R., Weiler, Andrea M., Semler, Matthew R., Barry, Gabrielle L., Zarbock, Katie R., Mohns, Mariel S., Breitbach, Meghan E., Schultz-Darken, Nancy, Peterson, Eric, Newton, Wendy, Mohr, Emma L., Capuano III, Saverio, Osorio, Jorge E., O’Connor, Shelby L., O’Connor, David H., Friedrich, Thomas C., Aliota, Matthew T.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727388/
https://ncbi.nlm.nih.gov/pubmed/29235456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02222-8
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