טוען...
Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase
The two isoforms of the Bcr-Abl tyrosine kinase, p210 and p190, are associated with different leukemias and have a dramatically different signaling network, despite similar kinase activity. To provide a molecular rationale for these observations, we study the Dbl-homology (DH) and Pleckstrin-homolog...
שמור ב:
הוצא לאור ב: | Nat Commun |
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Main Authors: | , , , , , , , , , , , , , , , , , , |
פורמט: | Artigo |
שפה: | Inglês |
יצא לאור: |
Nature Publishing Group UK
2017
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נושאים: | |
גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5727386/ https://ncbi.nlm.nih.gov/pubmed/29235475 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02313-6 |
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