Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase

The two isoforms of the Bcr-Abl tyrosine kinase, p210 and p190, are associated with different leukemias and have a dramatically different signaling network, despite similar kinase activity. To provide a molecular rationale for these observations, we study the Dbl-homology (DH) and Pleckstrin-homolog...

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Udgivet i:Nat Commun
Main Authors: Reckel, Sina, Gehin, Charlotte, Tardivon, Delphine, Georgeon, Sandrine, Kükenshöner, Tim, Löhr, Frank, Koide, Akiko, Buchner, Lena, Panjkovich, Alejandro, Reynaud, Aline, Pinho, Sara, Gerig, Barbara, Svergun, Dmitri, Pojer, Florence, Güntert, Peter, Dötsch, Volker, Koide, Shohei, Gavin, Anne-Claude, Hantschel, Oliver
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727386/
https://ncbi.nlm.nih.gov/pubmed/29235475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02313-6
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