Tear proteome analysis in ocular surface diseases using label-free LC-MS/MS and multiplexed-microarray biomarker validation

We analyzed the tear film proteome of patients with dry eye (DE), meibomian gland dysfunction (MGD), and normal volunteers (CT). Tear samples were collected from 70 individuals. Of these, 37 samples were analyzed using spectral-counting-based LC-MS/MS label-free quantitation, and 33 samples were eva...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Soria, Javier, Acera, Arantxa, Merayo-LLoves, Jesús, Durán, Juan A., González, Nerea, Rodriguez, Sandra, Bistolas, Nikitas, Schumacher, Soeren, Bier, Frank F., Peter, Harald, Stöcklein, Walter, Suárez, Tatiana
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727318/
https://ncbi.nlm.nih.gov/pubmed/29234088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17536-2
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