IRF8-dependent molecular complexes control the Th9 transcriptional program

Interferon regulatory factors (IRF) have critical functions in lymphoid development and in immune response regulation. Although many studies have described the function of IRF4 in CD4(+) T cells, few have focused on the IRF4 homologue, IRF8. Here, we show that IRF8 is required for Th9 differentiatio...

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Vydáno v:Nat Commun
Hlavní autoři: Humblin, Etienne, Thibaudin, Marion, Chalmin, Fanny, Derangère, Valentin, Limagne, Emeric, Richard, Corentin, Flavell, Richard A., Chevrier, Sandy, Ladoire, Sylvain, Berger, Hélène, Boidot, Romain, Apetoh, Lionel, Végran, Frédérique, Ghiringhelli, François
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727025/
https://ncbi.nlm.nih.gov/pubmed/29233972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01070-w
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