An Integrative Approach to Assess X-Chromosome Inactivation Using Allele-Specific Expression with Applications to Epithelial Ovarian Cancer

X-chromosome inactivation (XCI) epigenetically silences transcription of an X chromosome in females; patterns of XCI are thought to be aberrant in women’s cancers, but are understudied due to statistical challenges. We develop a two-stage statistical framework to assess skewed XCI and evaluate gene-...

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Pubblicato in:Genet Epidemiol
Autori principali: Larson, Nicholas B., Fogarty, Zachary C., Larson, Melissa C., Kalli, Kimberly R., Lawrenson, Kate, Gayther, Simon, Fridley, Brooke L., Goode, Ellen L., Winham, Stacey J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5726546/
https://ncbi.nlm.nih.gov/pubmed/29119601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.22091
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